Top 20 Best-Selling Pharma Brands
- G-Med Team

- 1 day ago
- 3 min read
The pharmaceutical landscape in 2024 is a story of power, innovation, and shifting trends. From oncology blockbusters to metabolic disruptors, the top-selling drugs show us where medicine is heading and where marketers should focus. Here’s a breakdown of the top 20 drugs by global sales, and what each tells us about the market.

1. Keytruda (pembrolizumab) – Merck & Co.
Sales: ~$29.5B Keytruda remains the top-selling drug globally, thanks to expanded cancer indications and solid worldwide reach. This is the classic blockbuster story: big data, broad impact, high HCP engagement potential.
2. Eliquis (apixaban) – BMS/Pfizer
Sales: ~$20.7B This anticoagulant shows that mature therapies can still dominate if backed by consistent evidence and marketing. Real-world data campaigns keep physicians engaged.
3. Ozempic (semaglutide) – Novo Nordisk
Sales: ~$17.5BGLP-1 therapies exploded in 2024. Ozempic is redefining diabetes and obesity care, crossing traditional specialty lines and creating new HCP marketing opportunities.
4. Dupixent (dupilumab) – Sanofi/Regeneron
Sales: ~$14.1B Dupixent continues to expand in immunology indications. Multi-indication marketing and strong clinical data make it a physician favorite.
5. Biktarvy – Gilead Sciences
Sales: ~$13.4B HIV therapy remains stable and high-value. Specialist engagement and clear clinical outcomes drive adoption.
6. Jardiance family – Boehringer Ingelheim / Eli Lilly
Sales: ~$12.4B Cardio-metabolic convergence drives growth. Cross-specialty physician engagement is key.
7. Skyrizi (risankizumab) – AbbVie
Sales: ~$11.7B Rapid growth via indication expansion highlights the power of immunology therapies.
8. Darzalex (daratumumab) – Johnson & Johnson
Sales: ~$11.7B Multiple myeloma treatment that demonstrates consistent adoption through strong clinical evidence.
9. Mounjaro (tirzepatide) – Eli Lilly
Sales: ~$11.5B Another GLP-1, showing the continuing appetite for metabolic therapies and multi-specialty engagement.
10. Stelara (ustekinumab) – Johnson & Johnson
Sales: ~$10.4B Mature immunology therapy facing biosimilar pressure, a case study in lifecycle marketing.
11. Trikafta (elexacaftor/tezacaftor/ivacaftor) – Vertex
Sales: ~$11.0B Rare disease blockbuster demonstrating the value of precision medicine.
12. Opdivo (nivolumab) – BMS
Sales: ~$9.3B Immune-oncology remains competitive, with HCP education critical for adoption.
13. Humira (adalimumab) – AbbVie
Sales: ~$9.0B Once the global leader, now declining due to biosimilars — a reminder of lifecycle risk.
14. Gardasil / Gardasil 9 – Merck
Sales: ~$8.6B Vaccines remain steady, showing that prevention drives sustained revenue.
15. Wegovy (semaglutide) – Novo Nordisk
Sales: ~$8.4B Obesity-focused GLP-1 confirms that metabolic care is a new growth pillar.
16. Xtandi (enzalutamide) – Astellas/Pfizer
Sales: ~$7.9B Prostate cancer therapy showing niche specialty strength.
17. Entresto – Novartis
Sales: ~$7.8B Heart failure treatment highlighting the importance of multi-specialty cardiology engagement.
18. Ocrevus – Roche
Sales: ~$7.7B MS therapy maintaining its strong presence in chronic neurology.
19. Tagrisso – AstraZeneca
Sales: ~$6.6B Precision oncology leader demonstrating targeted therapy growth.
20. Prevnar family – Pfizer
Sales: ~$6.4B Vaccines continue to generate stable revenue across markets.
Key Trends from 2024’s Top Drugs
Metabolic & Obesity Therapies are Surging – Novo Nordisk and Eli Lilly dominate with GLP-1 drugs.
Immunology & Oncology Remain Core – Multi-indication expansion drives physician adoption and revenue.
Lifecycle Management Matters – Humira’s decline shows even giants must evolve.
Specialist Engagement is Crucial – High-value therapies rely on targeted HCP education.
Global Market Matters – Top-selling drugs have worldwide adoption; localizing content for HCPs is key.
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